Medical Research News They report these findings in the January 2009 issue of The American Journal of Pathology. Bacteria contribute to the development of certain cancers, in some measure, by stimulating chronic inflammation. Absence of a molecule that inhibits inflammation, Smad3, may therefore increase susceptibility to colon cancer. To examine whether Smad3 signaling contributes to development of colon cancer, Maggio-Price et al examined mice deficient in Smad3 that lack of adaptive immune responses. They found that these mice are acutely sensitive to bacterially-induced inflammation and cancer due to both deficient T regulatory cell function and increased expression of proinflammatory cytokines. Through increased expression of both pro-oncogenic and anti-apoptotic proteins, epithelial cells in colonic tissues underwent both enhanced proliferation and survival. "That the inflammatory response to microorganisms is a key event in these results reveals important 'tumor-suppressive' functions for Smad3 in T effector cells, T regulatory cells, and intestinal epithelial cells, all of which may normally limit the development of colon cancer in response to bacterial inflammation," explains the groups led by Dr. Maggio-Price and Dr. Iritani.
Inflammation contributes to colon cancer
Published: Wednesday, 21-Jan-2009
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Researchers led by Drs. Lillian Maggio-Price and Brian Iritani at The University of Washington found that mice that lack the immune inhibitory molecule Smad3 are acutely sensitive to both bacterially-induced inflammation and cancer.
Thursday, January 22, 2009
Inflammation and Colon Cancer
There was a previous article like this I remember. It basically said that when you eat lots of food that your body has a hard time digesting (toxins, red meat, etc.) that your intestines actually get inflammed. Inflammation in the digestive tract is never a good thing, obviously, and continued inflammation can lead to cancer over a long time. I really believe that digestive health is as important as heart health ~ especially in our family.
XOXO
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