Association between vitamin D and risk of colorectal cancer identified
January 2010 00:04
Research: Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations: A nested case-control study.
High blood levels of vitamin D are associated with a lower risk of colon cancer finds a large European study published on today. The risk was cut by as much as 40% in people with the highest levels compared with those in the lowest. Several previous studies have already suggested a link between vitamin D and colorectal cancer, but the evidence has been inconclusive with limited information from European populations.
So, researchers from across Europe set out to examine the association between circulating vitamin D concentration as well as dietary intakes of vitamin D and calcium with colorectal cancer risk in Western European populations.
Their findings are based on the European Prospective Investigation into a study of over 520,000 subjects from 10 Western European countries.
Between 1992 and 1998, participants completed detailed dietary and lifestyle questionnaires and blood samples were collected. The subjects were then tracked for several years, during which time 1,248 cases of colorectal cancer were diagnosed and these were matched to 1,248 healthy controls.
Participants with the highest levels of blood vitamin D concentration had a nearly 40% decrease in colorectal cancer risk when compared to those with the lowest levels.
However, some recent publications have suggested maintenance of blood vitamin D levels at 50 nmol/l or higher for colorectal cancer prevention.
Thus, the authors also compared low and high levels of blood vitamin D concentration to a mid-level of 50-75 nmol/l. This comparison showed that while levels below the mid-level were associated with increased risk, those above 75 nmol/l were not associated with any additional reduction in colon cancer risk compared to the mid-level.
Although the results support a role for vitamin D in the etiology of colorectal cancer, the authors caution that very little is known about the association of vitamin D with other cancers and that the long term health effects of very high circulating vitamin D concentrations, potentially obtained by taking supplements and/or widespread fortification of some food products, have not been well studied.
With respect to colorectal cancer protection, it is still unclear whether inducing higher blood vitamin D concentration by supplementation is better than average levels that can be achieved with a balanced diet combined with regular and moderate exposure to outdoor sunlight, they say.
The findings of previous randomised trials have been inconsistent. As such, new trials should be carried out to evaluate whether increases in circulating vitamin D concentration can effectively reduce colorectal cancer risk without inducing serious adverse events, they conclude. Currently, the best recommendation to reduce ones risk of colorectal canceris to stop smoking, increase physical activity, reduce obesityand abdominal fatness, and limit intakes of alcohol and red and processed meats.
Source: BMJ-British Medical Journal
Washington Post
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Some foods are simply better than others. So we put this question to three local nutrition experts: If you could pick just a handful of ingredients to incorporate into your clients' diets, what would they be? Here are items that can have a long-term effect on health and well-being, according to North Potomac nutritionist Kelly Dorfman; Dana Laake, owner of Dana Laake Nutrition in Kensington; and D.C. health counselor Casey Seidenberg:
BLUEBERRIES Fresh or frozen, blueberries have one of the highest concentrations among fruits of antioxidants and phytochemicals (which fight disease and inflammation). They also tend to rank low in pesticide contamination. They are naturally sweet (unlike cranberries), yet they do not raise blood sugar significantly.
BROCCOLI AND OTHER DARK GREENS It has been proved again and again that Mom was right about eating your broccoli (and cauliflower and Brussels sprouts). Researchers continue to uncover the health benefits of one phytochemical in particular, sulforaphane, that is found in these vegetables, as well as in bok choy, kale, collard greens and watercress.
CACAO You'll often see dark chocolate turn up on "superfood" lists because it contains blood-pressure-lowering plant phenols and loads of antioxidants. Cacao, or raw chocolate, is even better because it lacks sugar and other additives. Though bitter, the whole beans or nibs can be eaten plain. In its powder form, cacao can be mixed into a smoothie or pancake batter, making it taste much like the guilty pleasure we all know and love.
QUINOA Though considered a grain, quinoa is a seed that has the same versatility as rice or barley but with even greater nutritional value and no gluten. It's a complete protein, meaning that it contains a balanced set of essential amino acids, which come only from diet. It also has fiber and such key nutrients as phosphorus, magnesium and iron.
SARDINES These, and other small fish, are becoming increasingly popular, and rightly so because of their lower concentrations of contaminants such as mercury. Most people are familiar with the canned variety, but sardines also are available fresh. They are rich in omega-3 fatty acids, which maintain heart health, and they're a significant source of calcium.
Denise DiFulco is a freelance writer.

